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Demographic history of India and mtDNA-sequence diversity

Mountain, JL and Hebert, JM and Bhattacharyya, SK and Underhill, PA and Ottolenghi, C and Gadgil, M and Cavalli-Sforza, LL (1995) Demographic history of India and mtDNA-sequence diversity. In: American Journal of Human Genetics, The, 56 (4). pp. 979-992.

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The demographic history of India was examined by comparing mtDNA sequences obtained from members of three culturally divergent Indian subpopulations (endogamous caste groups). While an inferred tree revealed some clustering according to caste affiliation, there was no clear separation into three genetically distinct groups along caste lines. Comparison of pairwise nucleotide difference distributions, however, did indicate a difference in growth patterns between two of the castes. The Brahmin population appears to have undergone either a rapid expansion or steady growth. The low-ranking Mukri caste, however, may have either maintained a roughly constant population size or undergone multiple bottlenecks during that period. Comparison of the Indian sequences to those obtained from other populations, using a tree, revealed that the Indian sequences, along with ah other non-African samples, form a starlike cluster. This cluster may represent a major expansion, possibly originating in southern Asia, taking place at some point after modern humans initially left Africa.

Item Type: Journal Article
Publication: American Journal of Human Genetics, The
Publisher: American Society of Human Genetics
Additional Information: Copyright of this article belongs to American Society of Human Genetics.
Department/Centre: Division of Biological Sciences > Centre for Ecological Sciences
Date Deposited: 15 Jun 2011 09:01
Last Modified: 15 Jun 2011 09:01
URI: http://eprints.iisc.ac.in/id/eprint/37517

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