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Mismatch repair genes of eukaryotes

Vani, Geeta R and Rao, MRS (1996) Mismatch repair genes of eukaryotes. In: Journal of Genetics, 75 (2). pp. 181-192.

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Mismatches that arise during replication or genetic recombination or owing to damage to DNA by chemical agents are recognized by mismatch repair systems. The pathway has been characterized in detail in Escherichia coli. Several homologues of the genes encoding the proteins of this pathway have been identified in the yeast Saccharomyces cerevisiae and in human cells. Mutations in the human genes hMSH2, hMLH1, hPMS1 and hPMS2 have been linked to hereditary nonpolyposis colon cancer (HNPCC) and to some sporadic tumours. Mismatch repair also plays an antirecombinogenic role and is implicated in speciation.

Item Type: Journal Article
Publication: Journal of Genetics
Publisher: Indian Academy of Sciences
Additional Information: Copyright of this article belongs to Indian Academy of Sciences.
Keywords: Mismatch repair;eukaryotes;cancer
Department/Centre: Division of Biological Sciences > Biochemistry
Date Deposited: 07 May 2011 05:23
Last Modified: 07 May 2011 05:23
URI: http://eprints.iisc.ac.in/id/eprint/37410

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