Subramanian, S and Adiga, PR (1996) Hormonal modulation of secretion of immunoreactive riboflavin carrier protein by adult rat Leydig cells in vitro. In: Indian Journal of Biochemistry & Biophysics, 33 (4). pp. 274-280.
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Adult rat Leydig cells in culture synthesize and secrete riboflavin carrier protein (RCP) as demonstrated by [S-35]-methionine incorporation into newly synthesized proteins followed by immunoprecipitation as well as specific radioimmunoassay. LH stimulates the secretion of RCP 4-fold which could be inhibited upto 75% by an aromatase inhibitor. 8-bromo-cyclic AMP and cholera toxin could mimic the LH stimulated secretion of the carrier protein. The extent of stimulation of RCP secretion brought about by exogenous estradiol-17 beta is comparable to that of LH. The antiestrogen tamoxifen, when added along with either LH or estrogen, inhibited the stimulated levels significantly. These results show that the estrogen-inducible riboflavin carrier is secreted by Leydig cells under positive regulation of LH.
| Item Type: | Journal Article |
|---|---|
| Publication: | Indian Journal of Biochemistry & Biophysics |
| Publisher: | National institute of science communication and information resources |
| Additional Information: | Copyright of this article belongs to National institute of science communication and information resources. |
| Department/Centre: | Division of Biological Sciences > Biochemistry |
| Date Deposited: | 28 Apr 2011 09:54 |
| Last Modified: | 23 Oct 2018 10:06 |
| URI: | http://eprints.iisc.ac.in/id/eprint/37286 |
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