Design, synthesis, and evaluation of bile acid-based molecular tweezers

DSouza, Lawrence J and Maitra, Uday (1996) Design, synthesis, and evaluation of bile acid-based molecular tweezers. In: Journal of Organic Chemistry, 61 (26). pp. 9494-9502.

PDF Design,_Synthesis,_and.pdf - Published Version Restricted to Registered users only Download (592kB) | Request a copy

Abstract

A family of bile acid-based molecular tweezers (7-9) has been constructed readily from simple precursors. Binding experiments with various electron deficient aromatic compounds showed that tweezer 8 binds trinitrofluorenone 10e with an association constant of 220 M(-1) in CDCl3. Single-crystal X-ray analysis of compound 8 shows aromatic-aromatic interactions producing a two-dimensional lattice of pyrene units. Tweezer 8 was immobilized on Merrifield resin, and binding studies have shown that these data compare well with those of the solution state studies.

Item Type:	Journal Article
Publication:	Journal of Organic Chemistry
Publisher:	American chemical society
Additional Information:	Copyright of this article belongs to American chemical society.
Department/Centre:	Division of Chemical Sciences > Organic Chemistry
Date Deposited:	07 May 2011 05:49
Last Modified:	07 May 2011 05:49
URI:	http://eprints.iisc.ac.in/id/eprint/37106

Actions (login required)

View Item