A large conductance Ca2+-activated K+ channel in alpha T3-1 pituitary gonadotrophs

Tiwari, JK and Adhikari, A and Sikdar, SK (1996) A large conductance Ca2+-activated K+ channel in alpha T3-1 pituitary gonadotrophs. In: Current Science (Bangalore), 70 (9). pp. 849-853.

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Abstract

The Ca2+-activated K+ channel in endocrine cells is responsible for membrane hyperpolarization and rhythmic firing of action potentials. The probability of opening of this channel is sensitive to intracellular-free Ca2+ concentration. In this study we have identified one such large conductance Ca2+-activated K+ channel in alpha T3-1 pituitary gonadotroph cell. This channel is ohmic with a unit conductance of 170 pS in symmetrical KCl (135 mM) and its current reverses near zero millivolts. When more than one channel is present in the patch membrane they open and close independent of each other, exhibiting no cooperativity between them as expected of a binomial distribution. The regulatory mechanism of this channel in modulating hormone secretion from alpha T3-1 gonadotroph cells is indicated.

Item Type:	Journal Article
Publication:	Current Science (Bangalore)
Publisher:	Indian academy of sciences
Additional Information:	Copyright of this article belongs to Indian academy of sciences.
Department/Centre:	Division of Biological Sciences > Molecular Biophysics Unit
Date Deposited:	19 May 2011 07:30
Last Modified:	19 May 2011 07:30
URI:	http://eprints.iisc.ac.in/id/eprint/37003

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