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Antibodies raised against guanosine bind to double-stranded DNA

Kala, KC and Antony, A (1995) Antibodies raised against guanosine bind to double-stranded DNA. In: Biochemistry & Molecular Biology International, 37 (2). pp. 305-312.

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Antibodies elicited against guanosine have been reported to bind to single-stranded DNA. Using an avidin-biotin microELISA, we report that these antibodies also bind to double-stranded DNA. The binding is specific and is completely inhibited by the homologous hapten. The cross-reactivity of double-stranded DNA binding antibodies to single-stranded DNA is low. The antibodies are shown to bind to the topoisomers of plasmid DNA as assessed by a gel retardation assay.

Item Type: Journal Article
Publication: Biochemistry & Molecular Biology International
Publisher: Academic Press Aust
Additional Information: Copyright of this article belongs to Academic Press Aust.
Department/Centre: Division of Biological Sciences > Microbiology & Cell Biology
Date Deposited: 26 Apr 2011 06:21
Last Modified: 26 Apr 2011 06:21
URI: http://eprints.iisc.ac.in/id/eprint/36918

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