Regulation of diacylglycerol kinase in rat brain membranes by docosahexaenoic acid

Vaidyanathan, VV and Rao, Raja KV and Sastry, PS (1994) Regulation of diacylglycerol kinase in rat brain membranes by docosahexaenoic acid. In: Neuroscience Letters, 179 (1-2). 171-174 .

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Abstract

The effect of docosahexaenoic acid (DHA) on the diacylglycerol kinase (DG kinase) activity in rat brain membranes was investigated. DHA at 500 mu M concentration, stimulated the enzyme activity by about 2 fold. This effect was concentration-and time-dependent and was observed after very short periods of incubation (one min). DHA stimulation of DG kinase was observed only with rat brain membranes, and not with rat brain cytosol or rat liver membranes. Treating the rat brain membranes with phospholipase A(2) which released free fatty acids including DHA, significantly stimulated the DG kinase activity. It is concluded that DHA through its stimulatory effect on DG kinase may regulate the signalling events in growth-related situations in the brain such as synaptogenesis.

Item Type:	Journal Article
Publication:	Neuroscience Letters
Publisher:	Elsevier science
Additional Information:	Copyright of this article belongs to Elsevier science.
Keywords:	Docosahexaenoic acid;DG kinase;Stimulation;Rat brain membrane;Synaptogenesis
Department/Centre:	Division of Biological Sciences > Biochemistry
Date Deposited:	11 Apr 2011 06:32
Last Modified:	11 Apr 2011 06:32
URI:	http://eprints.iisc.ac.in/id/eprint/36785

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