Synthesis and in vitro cholesterol dissolution by 23- and 24-phosphonobile acids

Babu, Ponnusamy and Maitra, Uday (2005) Synthesis and in vitro cholesterol dissolution by 23- and 24-phosphonobile acids. In: Steroids, 70 (10). pp. 681-689.

Preview

PDF A150.pdf Download (153kB)

Abstract

A new class of 23- and 24-phosphonobile acids have been synthesized from bile acid and their in vitro cholesterol-dissolving efficiency have been estimated. 24-Phosphonobile salts (PBSs) are slightly more efficient in solubilizing cholesterol than 23-PBSs and natural bile salts. The cholesterol solubilizing power is influenced by the structure of PBSs, and is considerably reduced with an increase in the bulk pH.

Item Type:	Journal Article
Publication:	Steroids
Publisher:	Elsevier Science Inc
Additional Information:	Copyright for this article belongs to Elsevier.
Keywords:	Bile acids;Cholesterol dissolution;Gallstone dissolution;Phosphonobile acids
Department/Centre:	Division of Chemical Sciences > Organic Chemistry
Date Deposited:	05 Sep 2005
Last Modified:	19 Sep 2010 04:20
URI:	http://eprints.iisc.ac.in/id/eprint/3610

Actions (login required)

View Item