Polyelectrolyte microcapsules for sustained delivery of water-soluble drugs

Anandhakumar, S and Debapriya, M and Nagaraja, V and Raichur, Ashok M (2011) Polyelectrolyte microcapsules for sustained delivery of water-soluble drugs. In: Materials Science and Engineering: C, 31 (2). pp. 342-349.

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Abstract

Polyelectrolyte capsules composed of weak polyelectrolytes are introduced as a simple and efficient system for spontaneous encapsulation of low molecular weight water-soluble drugs. Polyelectrolyte capsules were prepared by layer-by-layer (LbL) assembling of weak polyelectrolytes, poly(allylamine hydrochloride) (PAH) and poly (methacrylic acid) (PMA) on polystyrene sulfonate (PSS) doped CaCO3 particles followed by core removal with ethylene-diaminetetraacetic add (EDTA). The loading process was observed by confocal laser scanning microscopy (CLSM) using tetramethylrhodamineisothiocyanate labeled dextran (TRITC-dextran) as a fluorescent probe. The intensity of fluorescent probe inside the capsule decreased with increase in cross-linking time. Ciprofloxacin hydrochloride (a model water-soluble drug) was spontaneously deposited into PAH/PMA capsules and their morphological changes were investigated by scanning electron microscopy (SEM) and atomic force microscopy (AFM). The quantitative study of drug loading was also elucidated which showed that drug loading increased with initial drug concentration, but decreased with increase in pH. The loaded drug was released in a sustained manner for 6 h, which could be further extended by cross-linking the capsule wall. The released drug showed significant antibacterial activity against E. coli. These findings indicate that such capsules can be potential carriers for water-soluble drugs in sustained/controlled drug delivery applications. (C) 2010 Elsevier B.V. All rights reserved.

Item Type:	Journal Article
Publication:	Materials Science and Engineering: C
Publisher:	Elsevier Science
Additional Information:	Copyright of this article belongs to Elsevier Science B.V.
Keywords:	Weak polyelectrolyte capsules;Ciprofloxacin;Encapsulation; Antibacterial studies
Department/Centre:	Division of Biological Sciences > Microbiology & Cell Biology Division of Mechanical Sciences > Materials Engineering (formerly Metallurgy)
Date Deposited:	07 Apr 2011 06:27
Last Modified:	07 Apr 2011 06:27
URI:	http://eprints.iisc.ac.in/id/eprint/36000

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