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Specificity in the regulation of eukaryotic gene transcription

Padmanaban, G (1993) Specificity in the regulation of eukaryotic gene transcription. In: Journal of Biosciences, 18 (1). pp. 27-36.

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The regulation of eukaryotic gene transcription poses major challenges in terms of the innumerable protein factors required to ensure tissue or cell-type specificity. While this specificity is sought to be explained by the interaction of cis-acting DNA elements and thetrans-acting protein factor(s), considerable amount of degeneracy has been observed in this interaction. Immunoglobulin heavy chain gene expression in B cells and liver-specific gene expression are discussed as examples of this complexity in this article. Heterodimerization and post-translational modification of transcription factors and the organization of composite promoter elements are strategies by which diverse sets of genes can be regulated in a specific manner using a finite number of protein factors

Item Type: Journal Article
Publication: Journal of Biosciences
Publisher: Indian Academy of Sciences
Additional Information: Copyright of this article belongs to Indian Academy of Sciences.
Keywords: Transcription in eukaryotes;regulation
Department/Centre: Division of Biological Sciences > Biochemistry
Date Deposited: 28 Feb 2011 08:34
Last Modified: 28 Feb 2011 08:35
URI: http://eprints.iisc.ac.in/id/eprint/35754

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