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Serotypic and genotypic characterization of human serotype 10 rotaviruses from asymptomatic neonates

Dunn, SJ and Greenberg, HB and Ward, RL and Nakagomi, O and Burns, JW and Vo, PT and Pax, KA and Das, M and Gowda, K and Rao, CD (1993) Serotypic and genotypic characterization of human serotype 10 rotaviruses from asymptomatic neonates. In: Journal of Clinical Microbiology, 31 (1). pp. 165-169.

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Human rotaviruses were isolated from asymptomatic neonates at various hospitals and clinics in the city of Bangalore, India, and were found to be subgroup I specific and possess long RNA patterns (M. Sukumaran, K. Gowda, P. P. Maiya, T. P. Srinivas, M. S. Kumar, S. Aijaz, R. R. Reddy, L. Padilla, H. B. Greenberg, and C. D. Rao, Arch. Virol. 126:239-251, 1992). Three of these strains were adapted to tissue culture and found by serotype analysis and neutralization assays to be of serotype 10, a serotype commonly found in cattle but infrequently found in humans and not previously identified in neonates. By RNA-RNA hybridization, a high level of relatedness to a serotype 10 bovine rotavirus strain and a low-to-medium level of relatedness to a human rotavirus strain were observed. Since this human isolate shares a genogroup with bovine rotavirus, it is likely that it originated by interspecies transmission. A human rotavirus strain isolated from asymptomatic neonates and similar to bovine rotavirus might represent a good vaccine candidate.

Item Type: Journal Article
Publication: Journal of Clinical Microbiology
Publisher: American Society for Microbiology
Additional Information: Copyright of this article belongs to American Society for Microbiology.
Department/Centre: Division of Biological Sciences > Microbiology & Cell Biology
Division of Biological Sciences > Molecular Reproduction, Development & Genetics
Date Deposited: 02 Mar 2011 06:36
Last Modified: 18 Oct 2011 06:58
URI: http://eprints.iisc.ac.in/id/eprint/35738

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