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Association analysis of 5HT transporter gene in bipolar disorder in the Indian population

Saleem, Q and Ganesh, S and Vijaykumar, M and Reddy, YCJ and Brahmachari, SK and Jain, Sanjeev (2000) Association analysis of 5HT transporter gene in bipolar disorder in the Indian population. In: American Journal of Medical Genetics, 96 (2). pp. 170-172.

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Official URL: http://onlinelibrary.wiley.com/doi/10.1002/%28SICI...


A variable number tandem repeat (VNTR) polymorphism consisting of multiple copies of a 17-bp repeat in the second intron of the serotonin transporter gene (SERT) has been reported. Different alleles of this VNTR have been found to be associated with bipolar disorder and schizophrenia. These findings have been confirmed in some populations, but disconfirmed in others. Furthermore, significant ethnic variations in the distribution of these alleles both in normal and patient populations also have been reported. We analyzed the VNTR polymorphism in 50 Indian patients with bipolar disorder and in ethnically matched controls. Two alleles corresponding to 10 and 12 repeats of the VNTR were found in both groups. There were no significant differences either in allele frequency or genotype frequency between the two groups. The nine-repeat allele that has been reported in Japanese and Caucasian populations was absent in our sample. Although it will be important to extend the present study in a larger sample, our initial results do not suggest any large association with alleles of the VNTR in the SERT gene and bipolar disorder in Indian patients.

Item Type: Journal Article
Publication: American Journal of Medical Genetics
Publisher: John Wiley and Sons
Additional Information: Copyright of this article belongs to John Wiley and Sons.
Keywords: bipolar disorder;serotonin transporter gene;sert;vtnr polymorphism
Department/Centre: Division of Biological Sciences > Molecular Biophysics Unit
Date Deposited: 24 Aug 2005
Last Modified: 08 Feb 2012 05:28
URI: http://eprints.iisc.ac.in/id/eprint/3549

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