Internally Stabilized Selenocysteine Derivatives: Syntheses, $^7^7$Se NMR and Biomimetic Studies

Phadnis, Prasad P and Mugesh, G (2005) Internally Stabilized Selenocysteine Derivatives: Syntheses, $^7^7$Se NMR and Biomimetic Studies. In: Organic and Biomolecular Chemistry, 3 (13). pp. 2476-2481.

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Abstract

Selenocystine $([Sec]_2)$ and aryl-substituted selenocysteine (Sec) derivatives are synthesized, starting from commercially available amino acid L-serine. These compounds are characterized by a number of analytical techniques such as NMR $(^1H, ^1^3C and ^7^7Se)$ and TOF mass spectroscopy. This study reveals that the introduction of amino/imino substituents capable of interacting with selenium may stabilize the Sec derivatives. This study further suggests that the oxidation-elimination reactions in Sec derivatives could be used for the generation of biologically active selenols having internally stabilizing substituents.

Item Type:	Journal Article
Publication:	Organic and Biomolecular Chemistry
Publisher:	Royal Society of Chemistry
Additional Information:	The copyright for this article belongs to Royal Society of Chemistry
Department/Centre:	Division of Chemical Sciences > Inorganic & Physical Chemistry
Date Deposited:	30 Sep 2005
Last Modified:	19 Sep 2010 04:19
URI:	http://eprints.iisc.ac.in/id/eprint/3545

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