Conformational Variability in Modified Nucleosides. Crystal and Molecular Structure of 2',3'-O-Isopropylidene Inosine

Mandea, Sharmila S and Shamala, N and Seshadri, TP and Viswamitra, MA (1992) Conformational Variability in Modified Nucleosides. Crystal and Molecular Structure of 2',3'-O-Isopropylidene Inosine. In: Nucleosides & Nucleotides, 11 (5). pp. 1103-1114.

PDF Conformational_Variability_in.pdf - Published Version Restricted to Registered users only Download (451kB) | Request a copy

Abstract

The crystal structure of 2',3'-O-isopropylidene inosine shows a number of interesting features. The four independent molecules in the asymmetric unit exhibit significant conformational variations. Ribose puckers fall in the O(4')-exo region, unfavourable in unsubstituted nucleosides. Hypoxanthine bases show base-pairing (I.I) in a manner analogous to the guanine self pairs (G.G) in 2',3'-O-isopropylidene guanosine but with a C(2)-H…O(6) hydrogen bond instead of N(2)-H…O(6).

Item Type:	Journal Article
Publication:	Nucleosides & Nucleotides
Publisher:	Marcel Dekker Inc
Additional Information:	Copyright of this article belongs to Marcel Dekker Inc.
Department/Centre:	Division of Physical & Mathematical Sciences > Physics
Date Deposited:	25 Jan 2011 06:02
Last Modified:	25 Jan 2011 06:02
URI:	http://eprints.iisc.ac.in/id/eprint/35149

Actions (login required)

View Item