Acute toxicity of methyl isocyanate in mammals. II. Induction of hyperglycemia, lactic acidosis, uraemia, and hypothermia in rats

Jeevaratnam, K and Vijayaraghavan, R and Kaushik, MP and Vaidyanathan, CS (1990) Acute toxicity of methyl isocyanate in mammals. II. Induction of hyperglycemia, lactic acidosis, uraemia, and hypothermia in rats. In: Archives of Environmental Contamination and Toxicology, 19 (3). pp. 314-318.

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Abstract

When rats were administered methyl isocyanate (MIC) by inhalation or subcutaneous route it produced severe hyperglycemia, clinical lactic acidosis, highly elevated plasma urea, and reduced plasma cholinesterase activity with unaltered erythrocytc acetyl cholinesterase activity. Irrespective of the route of administration, MIC also caused severe hypothermia, which was not ameliorated by prior administration of atropine sulphate. Acute toxic effects of MIC are essentially similar by either route except for the intensity of the effects

Item Type:	Journal Article
Publication:	Archives of Environmental Contamination and Toxicology
Publisher:	Springer
Additional Information:	Copyright of this article belongs to Springer.
Department/Centre:	Division of Biological Sciences > Biochemistry
Date Deposited:	06 Jan 2011 09:34
Last Modified:	06 Jan 2011 09:34
URI:	http://eprints.iisc.ac.in/id/eprint/34861

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