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Nature of the inhibition by noradrenaline of induction by cortisol of hepatic tryptophan pyrrolase

Sitaramam, V and Panini, SR and Rau, Meera and Ramasarma, T (1979) Nature of the inhibition by noradrenaline of induction by cortisol of hepatic tryptophan pyrrolase. In: Biochemical Pharmacology, 28 (1). pp. 77-81.

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Official URL: http://dx.doi.org/10.1016/0006-2952(79)90273-9


Administration of noradrenaline inhibited the induction of hepatic trytophan pyrrolase by Cortisol but not by tryptophan. The selective inhibition of pyrrolase was specific to noradrenaline, whereas adrenaline and rat growth hormone also inhibited tyrosine aminotransferase. None of those three hormones had any effect on the incorporation of [32P]-orthophosphate into RNA, stimulated by cortisol. Other biogenic amines, polypeptide hormones and steroid analogues were not inhibitory to the induction of tryptophan pyrrolase by cortisol. The α-adrenergic agonist, phenylephrine, potentiated the noradrenaline inhibition whereas Image -threo-3,4-dihydroxyphenylserine, its precursor, together with pargyline had no effect on the induction process of pyrrolase. These results support the view that noradrenaline exerts its inhibitory action at the cell membrane via the α-receptor, and is not mediated directly by an intracellular mechanism.

Item Type: Journal Article
Publication: Biochemical Pharmacology
Publisher: Elsevier Science
Additional Information: Copyright of this article belongs to Elsevier Science.
Department/Centre: Division of Biological Sciences > Biochemistry
Date Deposited: 16 Dec 2010 05:32
Last Modified: 16 Dec 2010 05:32
URI: http://eprints.iisc.ac.in/id/eprint/34524

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