Poly propyl ether imine (PETIM) dendrimer: A novel non-toxic dendrimer for sustained drug delivery

Jain, Subheet and Kaur, Amanpreet and Puri, Richa and Utreja, Puneet and Jain, Anubhuti and Bhide, Mahesh and Ratnam, Rakesh and Singh, Vinay and Patil, AS and Jayaraman, N and Kaushik, Gaurav and Yadav, Subodh and Khanduja, KL (2010) Poly propyl ether imine (PETIM) dendrimer: A novel non-toxic dendrimer for sustained drug delivery. In: European Journal of Medicinal Chemistry, 45 (11). pp. 4997-5005.

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Abstract

In the present study, an attempt was made to study the acute and sub-acute toxicity profile of G3-COOH Poly (propyl ether imine) PETIM] dendrimer and its use as a carrier for sustained delivery of model drug ketoprofen. Drug-dendrimer complex was prepared and characterized by FTIR, solubility and in vitro drug release study. PETIM dendrimer was found to have significantly less toxicity in A541 cells compared to Poly amido amine (PAMAM) dendrimer. Further, acute and 28 days sub-acute toxicity measurement in mice showed no mortality, hematological, biochemical or histopathological changes up to 80 mg/kg dose of PETIM dendrimer. The results of study demonstrated that G3-COOH PETIM dendrimer can be used as a safe and efficient vehicle for sustained drug delivery. (C) 2010 Elsevier Masson SAS. All rights reserved.

Item Type:	Journal Article
Publication:	European Journal of Medicinal Chemistry
Publisher:	Elsevier Science
Additional Information:	Copyright of this article belongs to Elsevier Science.
Keywords:	PETIM dendrimer; Drug delivery; Sustained release; Hemolytic toxicity; Acute and sub-acute toxicity
Department/Centre:	Division of Chemical Sciences > Organic Chemistry
Date Deposited:	23 Dec 2010 10:17
Last Modified:	16 Jan 2013 11:15
URI:	http://eprints.iisc.ac.in/id/eprint/34327

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