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Approximation of Internal Refractive Index Variation Improves Image Guided Diffuse Optical Tomography of Breast

Jagannath, Ravi Prasad K and Yalavarthy, Phaneendra K (2010) Approximation of Internal Refractive Index Variation Improves Image Guided Diffuse Optical Tomography of Breast. In: IEEE Transactions on Biomedical Engineering, 57 (10, Pa). pp. 2560-2563.

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Effective usage of image guidance by incorporating the refractive index (RI) variation in computational modeling of light propagation in tissue is investigated to assess its impact on optical-property estimation. With the aid of realistic patient breast three-dimensional models, the variation in RI for different regions of tissue under investigation is shown to influence the estimation of optical properties in image-guided diffuse optical tomography (IG-DOT) using numerical simulations. It is also shown that by assuming identical RI for all regions of tissue would lead to erroneous estimation of optical properties. The a priori knowledge of the RI for the segmented regions of tissue in IG-DOT, which is difficult to obtain for the in vivo cases, leads to more accurate estimates of optical properties. Even inclusion of approximated RI values, obtained from the literature, for the regions of tissue resulted in better estimates of optical properties, with values comparable to that of having the correct knowledge of RI for different regions of tissue.

Item Type: Journal Article
Publication: IEEE Transactions on Biomedical Engineering
Publisher: IEEE
Additional Information: Copyright of this article belongs to IEEE.
Keywords: Biomedical optical imaging; image reconstruction; image registration; optical tomography
Department/Centre: Division of Interdisciplinary Sciences > Supercomputer Education & Research Centre
Date Deposited: 29 Nov 2010 12:11
Last Modified: 29 Nov 2010 12:11
URI: http://eprints.iisc.ac.in/id/eprint/33972

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