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Structural Investigations on Poly(4-hydroxy-L-proline). 2. Physicochemical Studies

Brahmachari, Samir K and Bansal, Manju and Ananthanarayanan, VS and Sasisekharan , V (1979) Structural Investigations on Poly(4-hydroxy-L-proline). 2. Physicochemical Studies. In: Macromolecules, 12 (1). pp. 23-28.

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We report experimental studies which confirm our prediction, namely that the ordered structure of poly(hydroxypro1ine) in solution corresponds to a left-handed helical structure with intrachain hydrogen bonds. The CD studies show that the poly(hydroxypro1ine) molecule has essentially the same conformation in aqueous solution and in the film obtained subsequently by evaporation. X-ray diffraction patterns of the sample in this form (B form) have been recorded at different relative humidities. The patterns recorded at relative humidities over 66% can be interpreted in terms of a helical structure with intrachain hydrogen bonds. These results lead us to conclude that the ordered conformation of poly(hydroxypro1ine) in solution is form B and not form A. This offers a simple explanation for the greater stability of the poly(hydroxypro1ine) helix in solution as compared to the poly(pro1ine) form I1 helix and also for the absence of mutarotation for poly(hydroxypro1ine).

Item Type: Journal Article
Publication: Macromolecules
Publisher: American Chemical Society
Additional Information: Copyright of this article belongs to American Chemical Society.
Department/Centre: Division of Biological Sciences > Molecular Biophysics Unit
Date Deposited: 27 Dec 2010 12:01
Last Modified: 27 Dec 2010 12:01
URI: http://eprints.iisc.ac.in/id/eprint/33953

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