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IgG4 Autoantibodies to DNA in Systemic Lupus erythematosus Patients

Nagpal, Sunil and Namboodiri, MSA and Rao, Subba BS and Rao, Subba PV (1991) IgG4 Autoantibodies to DNA in Systemic Lupus erythematosus Patients. In: International Archives of Allergy & Applied Immunology, 95 (1). pp. 1-6.

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The presence of DNA-specific IgG4 antibodies was demonstrated in the sera of patients with systemic lupus erythematosus (SLE) by a microtiter solid-phase radioimmunoassay. A patient with distal inter-phalangeal swelling and extensive ulcers in the oral cavity, seronegative for anti-DNA antibodies of the IgG isotype, was found to have anti-DNA autoantibodies exclusively of the IgG4 subclass. These autoantibodies directed against the dsDNA conformation cross-reacted with chondroitin sulfate, dermatan sulfate and heparin.

Item Type: Journal Article
Publication: International Archives of Allergy & Applied Immunology
Publisher: Karger, Allschwilerstrasse
Additional Information: Copyright of this article belongs to Karger, Allschwilerstrasse.
Keywords: Subclass Distribution;Antibodies;Serum;Glomerulonephritis; Chromatography;Nephritis;Diseases.
Department/Centre: Division of Biological Sciences > Biochemistry
Date Deposited: 18 Nov 2010 10:46
Last Modified: 18 Nov 2010 10:46
URI: http://eprints.iisc.ac.in/id/eprint/33872

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