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Estradiol - 17β induces polyaromatic hydrocarbon-inducible cytochrome P-450 in chicken liver

Murti, Ramana J and Adiga, PR and Padmanaban, G (1991) Estradiol - 17β induces polyaromatic hydrocarbon-inducible cytochrome P-450 in chicken liver. In: Biochemical and Biophysical Research Communications, 175 (3). 928-935 .

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Official URL: http://dx.doi.org/10.1016/0006-291X(91)91654-U


A cDNA clone has been isolated from a chicken liver library prepared against messenger RNA isolated after chronic estradiol-17β treatment. The clone, pP-450 IA - 61, has an insert of 900nt and the sequence shows high homology to CYPIA2 subfamily from four other species. A single injection of estradiol-17β to immature chicken results in a striking induction of mRNA hybridizing to labeled pP-450IA - 61. The probe also hybridizes to mRNA induced by 3 — methylcholanthrene in chicken. These results offer direct proof for the similarity in the mode of action at the transcriptional level of polyaromatic hydrocarbons and estrogenic compounds.

Item Type: Journal Article
Publication: Biochemical and Biophysical Research Communications
Publisher: Elsevier science
Additional Information: Copyright of this article belongs to Elsevier science.
Department/Centre: Division of Biological Sciences > Biochemistry
Date Deposited: 30 Nov 2010 08:13
Last Modified: 01 Mar 2012 05:55
URI: http://eprints.iisc.ac.in/id/eprint/33770

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