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Crystal structure of hexanediamine-glutamic acid complex

Ramaswamy, S and Murty, MRN (1991) Crystal structure of hexanediamine-glutamic acid complex. In: Current Science (Bangalore), 60 (3). pp. 173-176.

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Polyamines are some of the most important and ubiquitous small molecules that modulate several functions of plant, animal and bacterial cells. Despite the simplicity of their chemical structure, their specific interactions with other biomolecules cannot be explained solely on the basis of their electrostatic properties. To evolve a structural understanding on the specificity of these interactions it is necessary to determine the structure of complexes of polyamines with other, representative biomolecules. This paper reports the structure of the 1:2 complex of hexanediamine and L-glutamic acid. The complex crystallizes in the monoclonic space group P2(1) with a = 5.171(1) angstrom, b = 22.044(2) angstrom, c = 10.181(2) angstrom and beta = 104.51(1)-degrees. The structure was refined to an R factor of 6.6%. The structures of these complexes not only suggest the importance of hydrogen-bonding interactions of polyamines but also provide some insight into other complementary interactions probably important for the specificity of biomolecular interactions.

Item Type: Editorials/Short Communications
Publication: Current Science (Bangalore)
Publisher: Indian Academy of Sciences
Additional Information: Copyright of this article belongs to Indian Academy of Sciences.
Keywords: Refinement.
Department/Centre: Division of Biological Sciences > Molecular Biophysics Unit
Date Deposited: 16 Nov 2010 09:04
Last Modified: 16 Nov 2010 09:04
URI: http://eprints.iisc.ac.in/id/eprint/33727

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