Brown adipose tissue mitochondria are cytochrome c — subsaturated

Gaikwad, Amos S and Ramasarma, T and Kurup, Ramakrishna CK (1991) Brown adipose tissue mitochondria are cytochrome c — subsaturated. In: Molecular and Cellular Biochemistry, 105 (2). 119 -125.

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Abstract

The oxidative activity of mitochondria freshly isolated from brown adipose tissue of rats was stimulated two-fold on the addition of small concentrations of exogenous cytochrome c to the reaction medium. Loss of membrane-bound cytochrome c did not occur during isolation of mitochondria. Estimation of the high-affinity binding sites on the organelle membrane indicated that less than a third of these sites remained saturated with cytochrome c. The pigment is thus shown to be a functionally limiting electron transport component in brown adipose tissue.

Item Type:	Journal Article
Publication:	Molecular and Cellular Biochemistry
Publisher:	Springer
Additional Information:	Copyright of this article belongs to Springer.
Keywords:	BAT mitochondria;electron transport;stimulation;cytochrome c binding sites.
Department/Centre:	Division of Biological Sciences > Biochemistry
Date Deposited:	11 Nov 2010 08:09
Last Modified:	11 Nov 2010 08:09
URI:	http://eprints.iisc.ac.in/id/eprint/33693

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