Enantioselective total synthesis of a novel polyketide natural product(+)-integrasone, an HIV-1 integrase inhibitor

Mehta, Goverdhan and Roy, Subhrangsu (2005) Enantioselective total synthesis of a novel polyketide natural product(+)-integrasone, an HIV-1 integrase inhibitor. In: Chemical Communications (25). pp. 3210-3212.

Preview

PDF PV33.pdf Download (239kB)

Abstract

Enantioselective total synthesis of the recently isolated, novel polyketide natural product (+)-integrasone has been accomplished from the readily available Diels-Alder adduct of cyclopentadiene and p-benzoquinone. An enzymatically desymmetrized epoxyquinone building block has been elaborated through a series of regio-, chemo- and stereocontrolled steps to the final bicyclic framework of the natural product.

Item Type:	Journal Article
Publication:	Chemical Communications
Publisher:	Royal Society of Chemistry
Additional Information:	Copyright for this article belongs to Royal Society of Chemistry.
Department/Centre:	Division of Chemical Sciences > Organic Chemistry
Date Deposited:	21 Jul 2005
Last Modified:	19 Sep 2010 04:19
URI:	http://eprints.iisc.ac.in/id/eprint/3369

Actions (login required)

View Item