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Functional linkages can reveal protein complexes for structure determination

Eisenberg, D and Strong, M and Kim, SM and Bowers, PM and Pal, Debnath and Terwilliger, TC (2006) Functional linkages can reveal protein complexes for structure determination. In: FASEB Journa, 20 (5, Par). A1336.

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Official URL: http://www.fasebj.org/cgi/content/meeting_abstract...


The study of molecular machines, and protein complexes in general, is a growth area of biology. Is there a computational method for inferring which combinations of proteins in an organism are likely to form a crystallizable complex? We use the Protein Data Bank (PDB) to assess the usefulness of inferred functional protein linkages for this task. We find that of 242 nonredundant prokaryotic protein complexes (complexes excluding structural variants of the same protein) from organisms that are shared between the current PDB and the Prolinks functional linkage database, 44% (107/242) contain proteins that are linked at high-confidence by one or more methods of computed functional linkages. This suggests that computing functional linkages will be useful in defining protein complexes for structural studies. We offer a database of such inferred linkages corresponding to likely protein complexes for some 629,952 pairs of proteins in 154 prokaryotes and archea.

Item Type: Editorials/Short Communications
Publication: FASEB Journa
Publisher: Federation of American Societies for Experimental Biology.
Additional Information: Copyright of this article belongs to Federation of American Societies for Experimental Biology.
Department/Centre: Division of Interdisciplinary Sciences > Supercomputer Education & Research Centre
Date Deposited: 20 Oct 2010 09:11
Last Modified: 20 Oct 2010 09:11
URI: http://eprints.iisc.ac.in/id/eprint/32646

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