Chandrasekhar, I and Gaber, BP (1988) Stabilization of the bio-membrane by small molecules: interaction of trehalose with the phospholipid bilayer. In: Journal of Biomolecular Structure & Dynamics, 5 (6). 1163-&.
Full text not available from this repository. (Request a copy)Abstract
Anhydrobiotic organisms undergo periods of acute dehydration during their life cycle. It is of interest to understand how the biomembrane remains intact through such stress. A disaccharide, trehalose, which is metabolised during anhydrobiosis is found to prevent disruption of model membrane systems. Molecular modelling techniques are used to investigate the possible mode of interaction of trehalose with a model monolayer. The objective is to maximise hydrogen bonding between the two systems. A phospholipid matrix consisting of 1,2-dimyristoyl-sn-glycero-3-phosphatidylcholine (DMPC) is chosen to represent the monolayer. The crystal structure of DMPC reveals that there are two distinct conformers designated as A and B. An expansion of the monolayer, coplanar with its surface, results in the trehalose molecule being accommodated in a pocket formed by four B conformers. One glucose ring of the sugar rests on the hydrophobic patch provided by the choline methyls of an A conformer. Five hydrogen bonds are formed involving the phosphate oxygens of three of the surrounding B conformers. The model will be discussed with reference to relevant experimental data on the interaction.
| Item Type: | Journal Article |
|---|---|
| Publication: | Journal of Biomolecular Structure & Dynamics |
| Publisher: | Adenine Press |
| Additional Information: | Copyright of this article belongs to Adenine Press. |
| Department/Centre: | Division of Biological Sciences > Molecular Biophysics Unit |
| Date Deposited: | 04 Oct 2010 08:42 |
| Last Modified: | 04 Oct 2010 08:42 |
| URI: | http://eprints.iisc.ac.in/id/eprint/32566 |
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