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Sequence specificity of Z-DNA formation in oligonucleotides

Kadalayil, LP and Majumder, K and Mishra, RK and Brahmachari, SK (1988) Sequence specificity of Z-DNA formation in oligonucleotides. In: Biochemistry International, 17 (1). pp. 121-131.

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Official URL: http://www.ncbi.nlm.nih.gov/pubmed/3263858


The sequence specific requirement for B----Z transition in solution was examined in d(CGTGCGCACG), d(CGTACGTACG), d(ACGTACGT) in presence of various Z-inducing factors. Conformational studies show that inspite of the alternating nature of purines and pyrimidines, the aforementioned sequences do not undergo B----Z transition under the influence of NaCl, hexamine cobalt chloride and ethanol. A comparison with the crystal structures of an assorted array of purine and pyrimidine sequences show that the sequence requirement for B----Z transition is much more stringent in solution as compared to the solid state. The disruptive influence of AT base pairs in B to Z transition is discussed.

Item Type: Journal Article
Publication: Biochemistry International
Publisher: Academic Press Aust
Additional Information: Copyright of this article belongs to Academic Press Aust.
Department/Centre: Division of Biological Sciences > Molecular Biophysics Unit
Date Deposited: 04 Oct 2010 08:35
Last Modified: 04 Oct 2010 08:35
URI: http://eprints.iisc.ac.in/id/eprint/32542

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