Site of synthesis of cytochrome P-450 in liver

Bhat , Kolari S and Padmanaban, G (1978) Site of synthesis of cytochrome P-450 in liver. In: Biochemical and Biophysical Research Communications, 84 (1). pp. 1-6.

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Abstract

The suggestion that a rapidly sedimenting rough endoplasmic reticulum fraction in close association with mitochondria, is the preferred site of cytochrome P-450 synthesis has been examined. The rate of cytochrome P-450 synthesis in the different subcellular fractions has been evaluated Image , using the immunoprecipitation technique. The results indicate that the conventional microsomal fraction (100,000 X g sediment) is the major site of cytochrome P-450 synthesis and that the rapidly sedimenting rough endoplasmic reticulum fraction associated with mitochondria is not a preferred site for the hemoprotein synthesis.

Item Type:	Journal Article
Publication:	Biochemical and Biophysical Research Communications
Publisher:	Elsevier Science
Additional Information:	Copyright of this article belongs to Elsevier Science.
Department/Centre:	Division of Biological Sciences > Biochemistry
Date Deposited:	27 Sep 2010 11:39
Last Modified:	27 Sep 2010 11:39
URI:	http://eprints.iisc.ac.in/id/eprint/32460

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