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Thyroidal control of hepatic release and metabolism of vitamin A

Bhat , Krishna M and Cama, HR (1978) Thyroidal control of hepatic release and metabolism of vitamin A. In: Biochimica et Biophysica Acta (BBA), 541 (2). pp. 211-222.

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Official URL: http://dx.doi.org/10.1016/0304-4165(78)90394-X


The inverse relationship that exists between thyroxine and the vitamin A level of plasma has been examined in chicken. Thyroxine treatment leads to a decrease in the level of vitamin A carrier proteins, retinol-binding protein and prealbumin-2 in plasma and liver. There is an accumulation of vitamin A in the liver, with a greater proportion of vitamin A alcohol being present compared to that of control birds. In thyroxine treatment there is enhanced plasma turnover of retinol-binding protein and prealbumin-2, while their rates of synthesis are marginally increased. Amino acid supplementation partially counteracts effects of thyroxine treatment. Amino acid supplementation of thyroxine-treated birds does not alter the plasma turnover rates of retinol-binding protein and prealbumin-2 but increases substentially their rates of synthesis. The release of vitamin A into circulation is interfered with in hyperthyroidism due to inadequate availability of retinol-binding protein being caused by enhanced plasma turnover rate not compensated for by synthesis.

Item Type: Journal Article
Publication: Biochimica et Biophysica Acta (BBA)
Publisher: Elsevier Science
Additional Information: Copyright of this article belongs to Elsevier Science.
Department/Centre: Division of Biological Sciences > Biochemistry
Date Deposited: 27 Sep 2010 11:53
Last Modified: 27 Sep 2010 11:53
URI: http://eprints.iisc.ac.in/id/eprint/32453

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