Linear gramicidin activates neutrophil functions and the activation is blocked by chemotactic peptide receptor antagonist

Jacob, Jose (1988) Linear gramicidin activates neutrophil functions and the activation is blocked by chemotactic peptide receptor antagonist. In: FEBS Letters, 231 (1). pp. 139-142.

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Abstract

The activation of functional responses in rabbit peritoneal neutrophils by gramicidin and the chemotactic peptide, N-formyl-methionyl-leucyl-phenylalanine methyl ester, was studied. Gramicidin activated superoxide generation, lysosomal enzyme release and a decrease in fluorescence of chlortetracycline-loaded cells, as for the chemotactic peptide. The maximum intensities of the responses by gramicidin were lower than that by chemotactic peptide. Responses by both these peptides could be inhibited by t-butyloxycarbonyl-methionyl-leucyl-phenylalanine, a chemotactic peptide receptor antagonist. Gramicidin gave responses at low doses comparable to that of the chemotactic peptide.

Item Type:	Journal Article
Publication:	FEBS Letters
Publisher:	Elsevier science
Additional Information:	Copyright of this article belongs to Elsevier science.
Keywords:	Neutrophil;Chemotactic peptide;Gramicidin;Chemotactic peptide receptor;Superoxide;Lysosomal enzyme.
Department/Centre:	Division of Biological Sciences > Molecular Biophysics Unit
Date Deposited:	22 Sep 2010 10:11
Last Modified:	22 Sep 2010 10:11
URI:	http://eprints.iisc.ac.in/id/eprint/32350

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