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An association model for the solubilities of pharmaceuticals in supercritical carbon dioxide

Ch, Rajasekhar and Madras, Giridhar (2010) An association model for the solubilities of pharmaceuticals in supercritical carbon dioxide. In: Thermochimica Acta, 507-08 . pp. 99-105.

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Official URL: http://dx.doi.org/10.1016/j.tca.2010.05.006


The equilibrium solubility of a pharmaceutical compound. 1,5-dimethy1-2-phenyl-4-propan-2-ylpyrazol-3-one (propyphenazone, isopropylantipyrine) in supercritical carbon dioxide (SCCO2) was experimentally determined by a saturation method at 308, 318 and 328 K. over the pressure range of 9.0-19.0 MPa. The solubility data satisfied the self-consistency test, proposed by Mendez-Santiago and Teja. A new association model was derived to correlate the solubilities of pharmaceutical compounds in SCCO2. Solubility data from 54 different pharmaceutical compounds including steroids, antibiotics, anti-inflammatory, antioxidants, statins and specific functional drugs were collected from literature. The model successfully correlated the experimental results for the solubilities of all these compounds in SCCO2 within 12% AARD. (C) 2010 Elsevier B.V. All rights reserved.

Item Type: Journal Article
Publication: Thermochimica Acta
Publisher: Elsevier Science
Additional Information: Copyright of this article belongs to Elsevier Science.
Keywords: Solubilities; Association model;Isopropylantipyrine;Drugs; Supercritical fluids.
Department/Centre: Division of Mechanical Sciences > Chemical Engineering
Date Deposited: 20 Sep 2010 07:28
Last Modified: 20 Sep 2010 07:28
URI: http://eprints.iisc.ac.in/id/eprint/32241

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