Gonadotropin regulation of rat ovarian lysosomes: Existence of a hormone specific dual control mechanism

Dhanasekaran, N and Moudgal, NR (1988) Gonadotropin regulation of rat ovarian lysosomes: Existence of a hormone specific dual control mechanism. In: Bioscience Reports, 8 (3). pp. 279-285.

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Abstract

Gonadotropic hormones PMSG (15 IU/rat), FSH (3 mgrg/rat), LH (9 mgrg/rat) and hCG (3 mgrg/rat) were shown to decrease the free cytosolic lysosomal enzymes during the acute phase of hormone action in rat ovaries. When isolated cells from such rats were analyzed for the cathepsin-D activity, the granulosa cells of the ovary showed a reduction in the free as well as in the total lysosomal enzyme activities in response to FSH/PMSG; the stromal and thecal compartment of the ovary showed a reduction only in the free activity in response to hCG/PMSG. The results suggest the presence of two distinct, target cell specific, mechanisms by which the lysosmal activity of the ovary is regulated by gonadotropins.

Item Type:	Journal Article
Publication:	Bioscience Reports
Publisher:	Springer
Additional Information:	Copyright of this article belongs to Springer.
Keywords:	Gonadotropins;PMSG;FSH;LH;hCG;lysosomes;cathepsin-D.
Department/Centre:	Division of Biological Sciences > Biochemistry
Date Deposited:	18 Sep 2010 11:20
Last Modified:	19 Sep 2010 06:16
URI:	http://eprints.iisc.ac.in/id/eprint/32228

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