Ability of human chorionic gonadotropin beta-subunit to inhibit the steroidogenic response to lutropin

Dighe, RR and Muralidhar, K and Moudgal, NR (1979) Ability of human chorionic gonadotropin beta-subunit to inhibit the steroidogenic response to lutropin. In: Biochemical Journal, 180 (3). pp. 573-578.

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Abstract

Ability of the beta-subunit of human chorionic gonadotropin to inhibit the response to lutropin (luteinizing hormone, LH) was tested in the immature rat ovarian system and pregnant-mare-serum-gonadotropin-primed rat ovarian system with progesterone production being used as the response. Human chorionic gonadotropin beta-subunit was found to inhibit human and ovine lutropin-stimulated progesterone production. At a constant dose of lutropin, inhibition was dependent on the concentration of beta-subunit. When concentration of the beta-subunit was kept constant at 5.0 microgram/ml and the concentration of lutropin was varied, the inhibition was maximum at the saturating concentration of the native hormone. The alpha-subunit of the human chorionic gonadotropin did not inhibit the response to lutropin. The lutropin/beta-subunit ratio required to produce an inhibition of response was much lower than that required to bring about an observable inhibition of binding.

Item Type:	Journal Article
Publication:	Biochemical Journal
Publisher:	Portland Press
Additional Information:	Copyright of this article belongs to Portland Press.
Department/Centre:	Division of Biological Sciences > Biochemistry
Date Deposited:	21 Sep 2010 10:11
Last Modified:	21 Sep 2010 10:11
URI:	http://eprints.iisc.ac.in/id/eprint/32214

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