Assessment of the mutagenic potential of a fungicide Bavistin using multiple assays

Pandita, TK (1988) Assessment of the mutagenic potential of a fungicide Bavistin using multiple assays. In: Mutation Research/Genetic Toxicology, 204 (4). pp. 627-643.

PDF assesment.pdf - Published Version Restricted to Registered users only Download (1MB) | Request a copy

Abstract

The fungicide Bavistin was assessed for mutagenic potential by various assays. Bavistin was found to be unable to induce gene mutation in Salmonella typhimurium, but it was able to induce transfection inhibition in Mycobacterium smegmatis. Bavistin was able to induce immediate genotoxic effects in plants but these were not carried through in development as in the long term no genotoxic effects were observed by the progeny test. Bavistin did induce micronuclei formation and did cause an increase in the ratio of normochromatic to polychromatic erythrocytes in mice. It was able to induce a very low frequency of sister-chromatid exchange in human lymphocytes and in addition, it was observed that the chemical affected the mitotic index but did not affect the cell cycle duration. Present studies indicate that the pesticide shows a positive response in 4 out of 5 different test systems (Table 8) and most of the observations support that Bavistin is genotoxic.

Item Type:	Journal Article
Publication:	Mutation Research/Genetic Toxicology
Publisher:	Elsevier science
Additional Information:	Copyright of this article belongs to Elsevier science.
Keywords:	Potential;mutagenic;Bavistin;Fungicid;Bavistin.
Department/Centre:	Division of Biological Sciences > Microbiology & Cell Biology
Date Deposited:	06 Sep 2010 06:20
Last Modified:	19 Sep 2010 06:15
URI:	http://eprints.iisc.ac.in/id/eprint/32041

Actions (login required)

View Item