A Stereochemically-Constrained Enkephalin Analog: $\alpha-{Aminoisobutyryl}^2$ ${methionine}^5$ enkephalinamide

Nagaraj, R and Balaram, P (1978) A Stereochemically-Constrained Enkephalin Analog: $\alpha-{Aminoisobutyryl}^2$ ${methionine}^5$ enkephalinamide. In: FEBS Letters, 96 (2). pp. 273-276.

Preview

PDF analog.pdf Download (3MB)

Abstract

The discovery that the pentapeptides Tyr-Gly-Gly-Phe-Met (${Met}^5$-enkephalin) and Tyr-Gly-Gly-Phe-Leu (${Leu}^5$-enkephalin), present in the mammalian central nervous system [1,2], possess opioid activity has stimulated considerable interest in their conformations [3-15]. The enkephalins have been shown to bind to the opiate receptor in brain and displace naloxone, a powerful opiate antagonist [16]. The structures of the enkephalins have been the subject of a number of spectroscopic and theoretical investigations. There have been attempts to build a structural model for the pentapeptides that mimics the essential features of the morphine molecule [8-11]. From these studies conflicting suggestions have emerged about the low energy conformation of enkephalins and also the possible conformation of the pentapeptides at the opiate receptor site.

Item Type:	Journal Article
Publication:	FEBS Letters
Publisher:	Elsevier
Additional Information:	Copyright for this article belongs to Elsevier Science Ltd.
Department/Centre:	Division of Biological Sciences > Molecular Biophysics Unit Division of Chemical Sciences > Solid State & Structural Chemistry Unit
Date Deposited:	17 May 2005
Last Modified:	19 Sep 2010 04:18
URI:	http://eprints.iisc.ac.in/id/eprint/3191

Actions (login required)

View Item