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Structure of columbin, a diterpenoid furanolactone from Tinospora cordifolia Miers

Swaminathan, K and Sinha, UC and Ramakumar, S and Bhatt, RK and Sabata, BK (1989) Structure of columbin, a diterpenoid furanolactone from Tinospora cordifolia Miers. In: Acta Crystallographica Section C, 45 . 300 -303.

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(1S,4R,5R,8S, IOR,12S)-4-Hydroxy-15,16-epoxycleroda-2,13 (16), 14-trieno- 17,12:18,1-biscarbolactone,C20H2206, Mr = 358.2, m.p. = 453-454 K,orthorhombic, P212121, a = 7.3869 (6), b = 11.986 (1),c=19.896(2) A, V=1761.65A 3, Z=4, D x=1.351, Din(by flotation)= 1.349gem -3, 2(CuKa)=1.5418 A, /l = 8.36 cm -1, F(000) = 760, T= 295 K,R = 0.0432 for 1662 observed reflections. Two terpenerings, two ~-lactones, two methyl groups, a tertiary hydroxyl group and a fl-substituted furan ring are present in the structure. The H atoms at C(12) and C(8) are a- and fl-oriented. The terpene ring A is locked into a boat conformation by the C(1)-C(4) lactone bridge. The furan ring is attached equatoriaUy at atom C(12). The hydroxyl group is involved in intramolecular hydrogen bonding.

Item Type: Journal Article
Publication: Acta Crystallographica Section C
Publisher: International Union of Crystallography
Additional Information: Copyright of this article belongs to International Union of Crystallography
Department/Centre: Division of Physical & Mathematical Sciences > Physics
Date Deposited: 27 Aug 2010 09:46
Last Modified: 19 Sep 2010 06:15
URI: http://eprints.iisc.ac.in/id/eprint/31570

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