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Change in spectrum of Brownian fluctuations of optically trapped red blood cells due to malarial infection

Saraogi, Vishal and Padmapriya, P and Paul, Apurba and Tatu, Utpal S and Natarajan, Vasant (2010) Change in spectrum of Brownian fluctuations of optically trapped red blood cells due to malarial infection. In: Journal of Biomedical Optics, 15 (3).

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We study the properties of single red blood cells (RBCs) held in an optical-tweezers trap. We observe a change in the spectrum of Brownian fluctuations between RBCs from normal and malaria-infected samples. The change, caused by infection-induced structural changes in the cell, appears as a statistical increase in the mean (by 25%) and standard deviation (by 200%) of the corner frequency measured over similar to 100 cells. The increase is observed even though the ensemble of cells being measured consists mostly of cells that do not actually host the parasite, but are from an infected pool. This bystander effect appears to vindicate other observations that infected cells can affect the biomechanical properties of uninfected cells. The change is also observed to be independent of the stage of infection and its duration, highlighting its potential for disease detection. (C) 2010 Society of Photo-Optical Instrumentation Engineers. [DOI: 10.1117/1.3427142].

Item Type: Journal Article
Publication: Journal of Biomedical Optics
Publisher: The International Society for Optical Engineering
Additional Information: Copyright of this article belongs to The International Society for Optical Engineering.
Keywords: Optical tweezers;trap strength;RBC;malarial infection.
Department/Centre: Division of Biological Sciences > Biochemistry
Division of Physical & Mathematical Sciences > Physics
Date Deposited: 23 Aug 2010 09:45
Last Modified: 23 Aug 2010 09:45
URI: http://eprints.iisc.ac.in/id/eprint/31491

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