Redistribution of subcellular calcium in rat liver on administration of vanadate

Sharada, Gullapalli and Vidya, Shivaswamy and Ramasarma, T and Ramakrishna, Kurup CK (1989) Redistribution of subcellular calcium in rat liver on administration of vanadate. In: Molecular and Cellular Biochemistry, 90 (2). pp. 155-164.

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Abstract

Mitochondria isolated from the livers of rats administered with sodium meta-, ortho-, or polyvanadate, but not vanadyl sulphate, exhibited enhanced Ca2+ — stimulated respiration and uptake of calcium. These effects were shown also by mitochondria isolated from livers perfused with polyvanadate. The concentration of acid-soluble calcium decreased significantly in the mitochondrial fraction on vanadate treatment, while that in the cytosol showed a corresponding increase. Phenoxybenzamine, an antagonist to a-adrenergic receptors, effectively inhibited vanadate-induced Ca2+ mobilization, but surgical sympathectomy was without effect. This is the first demonstration of vanadate mimicking agr-adrenergic agonists in vivo.

Item Type:	Journal Article
Publication:	Molecular and Cellular Biochemistry
Publisher:	Springer
Additional Information:	Copyright of this article belongs to Springer.
Keywords:	polyvanadate;mitochondria;calcium;pyruvate dehydrogenase; receptors.
Department/Centre:	Division of Biological Sciences > Biochemistry
Date Deposited:	03 Aug 2010 08:48
Last Modified:	19 Sep 2010 06:13
URI:	http://eprints.iisc.ac.in/id/eprint/31104

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