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Monoclonal antibody derived peptide inhibitors for Mycobacterial DNA Gyrase

Valakunja, Nagaraja and Havaldar, Manjunath Ujjini and Nath, Roy Bhairab (2004) Monoclonal antibody derived peptide inhibitors for Mycobacterial DNA Gyrase. Patent Number(s) WO 2004026910 A1. Patent Assignee(s) Lupin Ltd.


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The present invention relates to the development of monoclonal antibodies that specifically inhibit DNA gyrase from M . tuberculosis, M . smegmatis and possibly from other related bacterial species. More particularly, it has been shown that the inhibition of the enzyme is by a hitherto unknown and novel mechanism. The present invention also relates to a DNA sequence of single chain antibody consisting of complementarity determining regions of mAb. The monoclonal antibody, single chain antibody and peptides derived thereof could be useful for developing lead molecules for tuberculosis therapy. The antibodies and derived materials could be useful for a variety of purposes, including diagnosis of mycobacterial infections. The present invention also relates to the modification of antibodies and derived materials for use against diverse microbial infections and other potential applications derived thereof.

Item Type: Patent
Department/Centre: Division of Biological Sciences > Microbiology & Cell Biology
Date Deposited: 15 Apr 2005
Last Modified: 19 Sep 2010 04:18
URI: http://eprints.iisc.ac.in/id/eprint/3070

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