Genomic imprinting: mom and dad (epi) genetics

Kumar, Arun (1999) Genomic imprinting: mom and dad (epi) genetics. In: Journal of Biosciences, 24 (1). pp. 4-6.

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Abstract

Genomic imprinting is an epigenetic chromosomal modification in the gametes or zygotes that results in a non-random monoallelic expression of specific autosomal genes depending upon their parent of origin. A gene could be maternally imprinted (only paternal copy expressed) or paternally imprinted (only maternal copy expressed). The exact mechanism of genomic imprinting is not clear. However, allele-specific methylation of CpG residues at the 5' end of imprinted genes is thought to be responsible for the maintenance of imprinting in somatic cells.

Item Type:	Journal Article
Publication:	Journal of Biosciences
Publisher:	Indian Academy of Sciences
Additional Information:	Copyright of this article belongs to Indian Academy of Sciences.
Department/Centre:	Division of Biological Sciences > Molecular Reproduction, Development & Genetics
Date Deposited:	18 Mar 2005
Last Modified:	19 Sep 2010 04:18
URI:	http://eprints.iisc.ac.in/id/eprint/2944

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