Export of proteins across membranes: The helix reversion hypothesis

Shinde, UP and Guru, Row TN and Mawal, YR (1989) Export of proteins across membranes: The helix reversion hypothesis. In: Bioscience Reports, 9 (6). pp. 737-745.

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Abstract

A model is presented which explains the biological role of the leader peptide in protein export. Along the lines of this model, the conformational changes of a protein with environment serves as a general mechanism for translocation. The leader peptide in the cytoplasm takes a hairpin like conformation which reverts to an extended helix upon integration into the membrane. The essential features of this model are in accord with recent results of protein export.

Item Type:	Journal Article
Publication:	Bioscience Reports
Publisher:	Springer
Additional Information:	Copyright of this article belongs to Springer.
Keywords:	protein export;conformational changes;leader peptides;hairpin helix.
Department/Centre:	Division of Chemical Sciences > Inorganic & Physical Chemistry
Date Deposited:	16 Jul 2010 06:24
Last Modified:	19 Sep 2010 06:11
URI:	http://eprints.iisc.ac.in/id/eprint/29299

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