Click chemistry inspired synthesis of ferrocene amino acids and other derivatives

Sudhir, Sai V and Kumar, Phani NY and Chandrasekaran, S (2010) Click chemistry inspired synthesis of ferrocene amino acids and other derivatives. In: Tetrahedron, 66 (6). pp. 1327-1334.

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Abstract

This work reports the synthesis of a wide range of ferrocenyl-amino acids and other derivatives in excellent yield. Diverse amino acid containing azides were synthesized and ligated to ferrocene employing click reaction to access ferrocenyl amino acids. Chiral alcohols, esters, diols, amines containing azido group were tagged to ferrocene via click reaction to generate ferrocene derived chiral derivatives. A novel strategy for direct incorporation of ferrocene into a peptide and a new route to 1, 1′disubstituted ferrocene amino acid derivative are reported.

Item Type:	Journal Article
Publication:	Tetrahedron
Publisher:	Elsevier Science
Additional Information:	Copyright of this article belongs to Elsevier Science.
Keywords:	Click chemistry; Ferrocene amino acids; Ferrocene based chiral derivatives; Cycloaddition
Department/Centre:	Division of Chemical Sciences > Organic Chemistry
Date Deposited:	15 Jul 2010 06:54
Last Modified:	19 Sep 2010 06:10
URI:	http://eprints.iisc.ac.in/id/eprint/28912

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