Porphyrin synthesis in drug induced hepatic porphyria

Rao, MR Sathyanarayana and Padmanaban, G and Sarma, PS (1971) Porphyrin synthesis in drug induced hepatic porphyria. In: Biochemical Pharmacology, 20 (8). pp. 2001-2007.

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Abstract

Liver δ-aminolaevulate (ALA) synthetase and ALA dehydratase are induced to a greater extent in 3,5-diethoxy carbonyl-1,4-dihydrocollidine (DDC) injected mice as compared to the allyl isopropyl acetamide (AIA) injected rats. DDC treated mice do not show an increase in porphobilinogen (PEG) levels commensurate with the increase in ALA levels and the two enzyme activities, but accumulate enormous quantities of protoporphyrin in the liver. Normal mouse liver has an inherent greater capacity to convert PBG to porphyrins as compared to that of the rat. This together with the inhibition of iron incorporation into protoporphyrin in vivo at later stages of DDC administration can account for the large accumulation of protoporphyrin in these animals.

Item Type:	Journal Article
Publication:	Biochemical Pharmacology
Publisher:	Elsevier Science
Additional Information:	Copyright of this article belongs to Elsevier Science.
Department/Centre:	Division of Biological Sciences > Biochemistry
Date Deposited:	15 Jun 2010 12:28
Last Modified:	19 Sep 2010 06:09
URI:	http://eprints.iisc.ac.in/id/eprint/28416

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