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Inhibition of Mycobacterial Growth by Plumbagin Derivatives

Mathew, Ritta and Kruthiventi, Anil K and Prasad, Jalli V and Kumar, Sadula P and Srinu, Garlapati and Chatterji, Dipankar (2010) Inhibition of Mycobacterial Growth by Plumbagin Derivatives. In: Chemical Biology & Drug Design, 76 (1). pp. 34-42.

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Official URL: http://www3.interscience.wiley.com/journal/1234153...


Electron transport and respiratory pathways are active in both latent and rapidly growing mycobacteria and remain conserved in all mycobacterial species. In mycobacteria, menaquinone is the sole electron carrier responsible for electron transport. Menaquinone biosynthesis pathway is found to be essential for the growth of mycobacteria. Structural analogs of the substrate or product of this pathway are found to be inhibitory for the growth of Mycobacterium,smegmatis and M. tuberculosis. Several plumbagin [5-hydroxy-2-methyl-1, 4-naphthaquinone] derivatives have been analyzed for their inhibitory effects of which butyrate plumbagin was found to be most effective on M. smegmatis mc2155, whereas crotonate plumbagin showed greater activity on M. tuberculosis H37Rv. Effect on electron transport and respiration was demonstrated by butyrate plumbagin inhibiting oxygen consumption in M. smegmatis. Structural modifications of these molecules can further be improved upon to generate new molecules against mycobacteria.

Item Type: Journal Article
Publication: Chemical Biology & Drug Design
Publisher: John Wiley and Sons
Additional Information: Copyright of this article belongs to John Wiley and Sons.
Keywords: FIC;inhibition;M;smegmatis;Menaquinone;MIC;plumbagin
Department/Centre: Division of Biological Sciences > Molecular Biophysics Unit
Date Deposited: 14 Jun 2010 07:31
Last Modified: 14 Jun 2010 07:31
URI: http://eprints.iisc.ac.in/id/eprint/28369

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