# Conformational Analysis of an Active Chemotactic Peptide Analog Containing Z-dehydrophbnylalanine at Position 3

Chauhan, VS and Kaur, Paramjeet and Sen, Nirupa and Uma, K and Jacob, Jose and Balaram, P (1988) Conformational Analysis of an Active Chemotactic Peptide Analog Containing Z-dehydrophbnylalanine at Position 3. In: Tetrahedron, 44 (8). pp. 2359-2366.

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$Formyl-Met-Leu-{\Delta}^z-Phe-Ome$, an analog of the chemotactic tripeptide Formyl-Met-Leu-Phe has been synthesized to evaluate the effect of substitution of \alpha, \beta-dehydrophenylalanine on activity and conformation. The analog peptide shows high biological activity in stimulating superoxide production by rabbit neutrophils. An NMR analysis of the solution conformation of the ${\Delta}^z-Phe$ analog, using nuclear Overhauser effects and comparisons with the corresponding saturated peptides, favours a significant population of extended backbone conformations.