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Vitamin C status of vitamin A-deficient rats

Seshadri Sastry, P and Malathi, P and Subba Rao, K and Ganguly, J (1962) Vitamin C status of vitamin A-deficient rats. In: Nature, 193 (4820). pp. 1080-1081. (Submitted)

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Official URL: http://www.nature.com/nature/journal/v193/n4820/ab...


IT was initially suggested that vitamin A-deficiency leads to an interference in the biosynthesis of ascorbic acid, because depletion of vitamin A was found to cause a fall in the tissue-levels of ascorbate and diminished urinary ascorbic acid excretion in animals1-3. Mapson4, however, concluded that lowered ascorbic acid-levels in vitamin A-deficient rats is due to inanition only, because he was able to show that following chloretone treatment vitamin A-deficient and pair-fed vitamin A normal rats excrete comparable amounts of ascorbic acid in their urine and that restriction of food intake reduces the urinary ascorbate even in the chloretone-treated normal rats. Results of our preliminary experiments reported here clearly indicate that the synthesis of ascorbic acid in rats is markedly reduced during vitamin A-deficiency.

Item Type: Journal Article
Publication: Nature
Publisher: Nature Publishing Group
Additional Information: Copyright of this article belongs to Nature Publishing Group.
Department/Centre: Division of Biological Sciences > Biochemistry
Date Deposited: 02 Jun 2010 09:05
Last Modified: 02 Jun 2010 09:05
URI: http://eprints.iisc.ac.in/id/eprint/28259

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