Joshi, VC and Ramasarma, T (1966) Biosynthesis of ubiquinone and ubichromenol in vitamin A-deficient rats. In: Biochimica et Biophysica Acta (BBA) - General Subjects, 115 (2). pp. 294-305.
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Abstract
1. The concentrations of ubiquinone and ubichromenol increased in the livers, but not in the intestines and kidneys, of rats maintained on a diet deficient in vitamin 2. After short time intervals (e.g. 2 h) following administration of the tracer, incorporation of [2-14C]mevalonate into ubiquinone and ubichromenol in livers of vitamin A-deficient rats was lower than for normal animals; this was in contrast to later times (e.g. 72 h) when it was higher. 3. The “newly synthesized” ubiquinone in livers of vitamin A-deficient rats was distributed in all the cell fractions without specific localization. 4. Absorbed exogenous [14C]ubiquinone and [14C]ubichromenol were retained in the livers of vitamin A-deficient rats to a larger extent and for a longer time than in the normal animals. 5. The results suggest that the accumulation of ubiquinone and ubichromenol in the livers of vitamin A-deficient rats is due to lowered catabolism and not to increased rate of synthesis.
Item Type: | Journal Article |
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Publication: | Biochimica et Biophysica Acta (BBA) - General Subjects |
Publisher: | Elsevier Science |
Additional Information: | Copyright of this article belongs to Elsevier Science. |
Department/Centre: | Division of Biological Sciences > Biochemistry |
Date Deposited: | 18 May 2010 07:02 |
Last Modified: | 19 Sep 2010 06:06 |
URI: | http://eprints.iisc.ac.in/id/eprint/27896 |
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