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Effect of dietary cholesterol and ubiquinone on isoprene synthesis in rat liver

Krishnaiah, KV and Joshi, VC and Ramasarma, T (1967) Effect of dietary cholesterol and ubiquinone on isoprene synthesis in rat liver. In: Archives of Biochemistry and Biophysics, 121 (1). pp. 147-153.

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Official URL: http://dx.doi.org/10.1016/0003-9861(67)90019-7


The effect of dietary cholesterol and ubiquinone on the synthesis of isoprene compounds in the liver, as tested by the incorporation of acetate-1-14C and mevalonate-2-14C, was studied in rats. In cholesterol feeding, there appears to be a second site of inhibition after squalene in addition to the previously known primary site of inhibition at the β-hydroxy-β-methyl glutaryl-CoA reductase. Feeding ubiquinone inhibited at some common step between acetate and mevalonate in the synthesis of both cholesterol and ubiquinone, without affecting the acetate activation or fatty acid synthesis, and also at a step in the synthesis of ubiquinone not common with the synthesis of cholesterol. These results are suggestive of a role for ubiquinone in the regulation of isoprene synthesis.

Item Type: Journal Article
Publication: Archives of Biochemistry and Biophysics
Publisher: ElsevierScience
Additional Information: Copyright of this article belongs to Elsevier Science.
Department/Centre: Division of Biological Sciences > Biochemistry
Date Deposited: 13 May 2010 06:23
Last Modified: 19 Sep 2010 06:06
URI: http://eprints.iisc.ac.in/id/eprint/27814

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