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Image -asparaginases from Mycobacterium tuberculosis strains H37Rv and H37Ra

Jayaram, HN and Ramakrishnan, TV and Vaidyanathan, CS (1968) Image -asparaginases from Mycobacterium tuberculosis strains H37Rv and H37Ra. In: Archives of Biochemistry and Biophysics, 126 (1). pp. 165-174.

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Official URL: http://dx.doi.org/10.1016/0003-9861(68)90570-5


M. tuberculosis H37Ra possesses two Image -asparaginases while the H37Rv strain possesses only a single enzyme. These enzymes have been purified and their properties studied. The two Image -asparaginases in H37Ra strain differ from each other in pH optima, heat inactivation, Michaelis constant and effects of inhibitors, while one of them resembles the single Image -asparaginase present in the H37Rv strain. Image -Cysteine inhibits both Image -asparaginases in an allosteric manner probably because it is one of the end-products in Image -asparagine metabolism. This is the first time that a qualitative difference has been reported in the enzyme pattern between the avirulent and virulent strains of M. tuberculosis.

Item Type: Journal Article
Publication: Archives of Biochemistry and Biophysics
Publisher: Elsevier Science
Additional Information: Copy right of this article belongs to Elsevier Science.
Department/Centre: Division of Biological Sciences > Biochemistry
Date Deposited: 14 May 2010 05:24
Last Modified: 19 Sep 2010 06:06
URI: http://eprints.iisc.ac.in/id/eprint/27728

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