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Metabolism of ubiquinone in relation to vitamin a status in the rat

Lakshmanan, MR and Cama, HR and Joshi, VC and Ramasarma, T (1968) Metabolism of ubiquinone in relation to vitamin a status in the rat. In: Biochimica et Biophysica Acta (BBA) - General Subjects, 170 (2). pp. 392-398.

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Official URL: http://dx.doi.org/10.1016/0304-4165(68)90018-4


1. 1. Biosynthetic experiments in vitro with slices of livers from normal and vitamin A-deficient rats confirmed that synthesis of ubiquinone did not increase in vitamin A deficiency. 2. 2. During development of deficiency of vitamin A in the rat, there was a definite increase in the synthesis of ubiquinone at the 10-days stage but this reverted to low, initial level by 20 days and after. 3. 3. Vitamin A analogues, 3-dehydroretinal, 5,6-monoepoxyretinal and retinoic acid, which supported growth have restored ubiquinone concentration to the normal levels and relieved the lowering in its catabolism. The biologically inert 5,8-monoepoxyretinal was the least active of the analogues tested. 4. 4. The concentration and synthesis of ubiquinone in the liver decreased under conditions of hypervitaminosis A. 5. 5. The experimental evidence does not support the hypothesis of inverse relationship between vitamin A and ubiquinone synthesis.

Item Type: Journal Article
Publication: Biochimica et Biophysica Acta (BBA) - General Subjects
Publisher: Elsevier Science
Additional Information: Copyright of this article belongs to Elsevier Science.
Department/Centre: Division of Biological Sciences > Biochemistry
Date Deposited: 17 May 2010 06:05
Last Modified: 19 Sep 2010 06:05
URI: http://eprints.iisc.ac.in/id/eprint/27665

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